Shimojima Masayuki, Nishimura Yorihiro, Miyazawa Takayuki, Tohya Yukinobu, Akashi Hiroomi
Department of Veterinary Microbiology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan.
Microbes Infect. 2004 Mar;6(3):265-71. doi: 10.1016/j.micinf.2003.12.002.
Feline immunodeficiency virus (FIV) infection induces an increase in two subpopulations (CD8alpha(+)beta(low) and CD8alpha(+)beta(-)) within CD8(+) peripheral blood lymphocytes (PBLs) of cats. It is known that depletion of CD8(+) cells often results in augmentation of FIV proliferation in PBL culture, similarly to the case of human immunodeficiency virus. In this study, we attempted to define PBL subpopulations mediating antiviral activity in five cats intravaginally infected with a molecularly cloned FIV isolate. Several subpopulations (CD8alpha(+)beta(+), CD8alpha(+)beta(-), and CD4(+) cells) were shown to participate in inhibition of the FIV replication, at least in part, in a major histocompatibility complex-unrestricted manner. Moreover, the subpopulations showing anti-FIV activity were different among the individual cats.
猫免疫缺陷病毒（FIV）感染会导致猫外周血淋巴细胞（PBL）中CD8⁺细胞的两个亚群（CD8α⁺β低和CD8α⁺β⁻）数量增加。已知CD8⁺细胞的耗竭通常会导致PBL培养物中FIV增殖增加，这与人类免疫缺陷病毒的情况类似。在本研究中，我们试图确定五只经阴道感染分子克隆FIV分离株的猫中介导抗病毒活性的PBL亚群。几个亚群（CD8α⁺β⁺、CD8α⁺β⁻和CD4⁺细胞）至少部分地以主要组织相容性复合体非限制性方式参与了对FIV复制的抑制。此外，表现出抗FIV活性的亚群在个体猫之间存在差异。
