在难治性癫痫患者中，宗教信仰与海马体体积相关，但与杏仁核体积无关。
Religiosity is associated with hippocampal but not amygdala volumes in patients with refractory epilepsy.
作者信息
Wuerfel J, Krishnamoorthy E S, Brown R J, Lemieux L, Koepp M, Tebartz van Elst L, Trimble M R
机构信息
Raymond Way Neuropsychiatry Research Group, University Department of Clinical Neurology, Institute of Neurology, Queen Square, London, UK.
出版信息
J Neurol Neurosurg Psychiatry. 2004 Apr;75(4):640-2. doi: 10.1136/jnnp.2003.06973.
OBJECTIVE
To assess the relationship between the behavioural triad of hyper-religiosity, hypergraphia and hyposexuality in epilepsy, and volumes of the mesial temporal structures.
METHOD
Magnetic resonance images were obtained from 33 patients with refractory epilepsy and mesial temporal structure volumes assessed. Amygdala and hippocampal volumes were then compared in high and low scorers on the religiosity, writing, and sexuality sub-scales of the Neurobehavioural Inventory.
RESULTS
Patients with high ratings on the religiosity scale had significantly smaller right hippocampi. Religiosity scores rated by both patient and carer showed a significant negative correlation with right hippocampal volumes in this group. There were no other differences in amygdala or hippocampal volumes between these groups, or between high and low scorers on the writing and sexuality sub-scales.
CONCLUSIONS
These findings suggest that right hippocampal volumes are negatively correlated with religiosity in patients with refractory epilepsy.
目的
评估癫痫患者中过度虔诚、书写癖和性欲减退行为三联征与内侧颞叶结构体积之间的关系。
方法
对33例难治性癫痫患者进行磁共振成像检查，并评估内侧颞叶结构体积。然后比较神经行为量表中宗教信仰、书写和性取向分量表得分高和得分低的患者的杏仁核和海马体体积。
结果
宗教信仰量表得分高的患者右侧海马体明显较小。该组患者及其护理人员评定的宗教信仰得分与右侧海马体体积呈显著负相关。这些组之间，以及书写和性取向分量表得分高和得分低的患者之间，杏仁核或海马体体积没有其他差异。
结论
这些发现表明，难治性癫痫患者的右侧海马体体积与宗教信仰呈负相关。
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