Masson C, Leys D, Meder J F, Dousset V, Pruvo J P
Service de Neurologie, Hôpital Beaujon, Clichy, France.
J Neuroradiol. 2004 Jan;31(1):35-46. doi: 10.1016/s0150-9861(04)96877-0.
Traditional data and recent advances in the field of spinal cord ischemia are reviewed, with special attention to clinical and radiological features, as well as underlying etiology, outcome, and pathophysiology. Acute spinal cord ischemia includes arterial and venous infarction and global ischemia resulting from cardiac arrest or severe hypotension. MRI has become the technique of choice for the imaging diagnosis of spinal cord infarction. Correlation of clinical and MRI data has allowed diagnosis of clinical syndromes due to small infarcts in the central or peripheral arterial territory of the spinal cord. Diffusion-weighted MR imaging may increase the sensitivity and specificity for diagnosis of acute spinal cord infarction. Diagnosis of venous spinal cord infarction remains difficult. As for global ischemia, neuropathological studies demonstrated a great sensitivity of spinal cord to ischemia, with selective vulnerability of lumbosacral neurons. Chronic spinal cord ischemia results in a syndrome of progressive myelopathy. The cause is usually an arteriovenous malformation. Most often, diagnosis may be suspected on MRI, leading to diagnostic, and eventually therapeutic, spinal angiography.
本文回顾了脊髓缺血领域的传统数据和最新进展,特别关注临床和放射学特征,以及潜在病因、预后和病理生理学。急性脊髓缺血包括动脉和静脉梗死以及心脏骤停或严重低血压导致的全脑缺血。MRI已成为脊髓梗死影像学诊断的首选技术。临床和MRI数据的相关性有助于诊断脊髓中央或外周动脉区域小梗死所致的临床综合征。扩散加权磁共振成像可能会提高急性脊髓梗死诊断的敏感性和特异性。静脉性脊髓梗死的诊断仍然困难。至于全脑缺血,神经病理学研究表明脊髓对缺血非常敏感,腰骶神经元具有选择性易损性。慢性脊髓缺血导致进行性脊髓病综合征。病因通常是动静脉畸形。大多数情况下,MRI可能会怀疑诊断,从而导致进行诊断性以及最终治疗性的脊髓血管造影。