Adin Christopher A, Farese James P, Cross Alan R, Provitola Mary K, Davidson Jeffrey S, Jankunas Hope
Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL 32610-0126, USA.
Am J Vet Res. 2004 Mar;65(3):283-8. doi: 10.2460/ajvr.2004.65.283.
To describe a percutaneously controlled static hydraulic urethral sphincter (SHUS) and evaluate urodynamic effects of the SHUS in canine cadavers.
Cadavers of 6 adult female dogs.
Cadavers were obtained immediately after dogs were euthanatized. Baseline maximal urethral closure pressure (MUCP) and cystourethral leak point pressure (CLPP) were measured by use of a urethral pressure profilometer. An SHUS system was constructed by use of a silicone vascular occluder and subcutaneous infusion port. The SHUS system was then placed around the pelvic urethra in each cadaver. Measurements of MUCP and CLPP were repeated after varying occlusion of the SHUS (0%, 25%, and 50% occlusion). Baseline MUCP and CLPP values were compared with values obtained at 0%, 25%, and 50% occlusion of the SHUS by use of repeated-measures ANOVA.
Mean +/- SD MUCP for canine cadavers was 7 +/- 1.3 cm H2O at baseline, which increased to 127 +/- 53 cm H2O after 50% occlusion of the SHUS. Mean CLPP was 11 +/- 8.6 cm H2O at baseline, which increased to 73 +/- 38 cm H2O after 50% occlusion of the SHUS. Mean MUCP and CLPP were significantly associated with the amount of occlusion.
The SHUS had positive effects on MUCP and CLPP in canine cadavers. Therefore, additional evaluation of the SHUS in live dogs is warranted.
描述一种经皮控制的静态液压尿道括约肌（SHUS），并评估其在犬类尸体中的尿动力学效应。
6只成年雌性犬的尸体。
犬只安乐死后立即获取尸体。使用尿道压力轮廓仪测量基线最大尿道闭合压（MUCP）和膀胱尿道漏点压（CLPP）。使用硅胶血管封堵器和皮下输注端口构建SHUS系统。然后将SHUS系统放置在每具尸体的盆腔尿道周围。在SHUS不同程度封堵（0%、25%和50%封堵）后重复测量MUCP和CLPP。使用重复测量方差分析将基线MUCP和CLPP值与SHUS 0%、25%和50%封堵时获得的值进行比较。
犬类尸体的平均±标准差MUCP在基线时为7±1.3 cm H2O，SHUS 50%封堵后增加到127±53 cm H2O。平均CLPP在基线时为11±8.6 cm H2O，SHUS 50%封堵后增加到73±38 cm H2O。平均MUCP和CLPP与封堵程度显著相关。
SHUS对犬类尸体的MUCP和CLPP有积极影响。因此，有必要在活体犬中对SHUS进行进一步评估。
