Craig T M, Hatfield T A, Pankavich J A, Wang G T
Department of Veterinary Pathobiology, Texas A & M University, College Station 77843.
Vet Parasitol. 1992 Mar;41(3-4):329-33. doi: 10.1016/0304-4017(92)90090-v.
The efficacy of moxidectin was determined against ivermectin-susceptible and resistant strains of Haemonchus contortus. At the onset of the trial, 40 lambs were each infected with 5000 third stage larvae of one of two strains of Haemonchus contortus. The lambs were randomly sorted into eight treatment groups 28 days post-infection and were treated as follows: Group 1, susceptible strain with no treatment; Group 2, resistant strain with no treatment; Group 3, susceptible strain treated with 0.2 mg moxidectin kg-1 body weight; Group 4, resistant strain treated with 0.2 mg moxidectin kg-1; Group 5, resistant strain treated with 0.4 mg moxidectin kg-1; Group 6, susceptible strain treated with 0.2 mg ivermectin kg-1; Group 7, resistant strain treated with 0.4 mg ivermectin kg-1; Group 8, resistant strain treated with 0.8 mg ivermectin kg-1. The lambs were killed 1 week post-treatment. Comparisons were made among groups based on the number of eggs per gram of feces on the day of treatment and the numbers of worms recovered from each lamb. Both moxidectin and ivermectin were effective in removing susceptible Haemonchus with efficacies of 100% and 99.7%, respectively. The efficacy of moxidectin against the resistant strain was 99.9% and 100% at 0.2 mg kg-1 and 0.4 mg kg-1, respectively, whereas there were only 38.8% and 53.1% efficacies in the lambs treated with 0.4 mg ivermectin kg-1 and 0.8 mg kg-1 body weight, respectively.
测定了莫昔克丁对伊维菌素敏感和耐药的捻转血矛线虫株的疗效。在试验开始时，40只羔羊分别感染了两种捻转血矛线虫株之一的5000条第三期幼虫。感染后28天，将羔羊随机分为8个治疗组，并进行如下处理：第1组，感染敏感株，未治疗；第2组，感染耐药株，未治疗；第3组，感染敏感株，用0.2毫克/千克体重的莫昔克丁治疗；第4组，感染耐药株，用0.2毫克/千克体重的莫昔克丁治疗；第5组，感染耐药株，用0.4毫克/千克体重的莫昔克丁治疗；第6组，感染敏感株，用0.2毫克/千克体重的伊维菌素治疗；第7组，感染耐药株，用0.4毫克/千克体重的伊维菌素治疗；第8组，感染耐药株，用0.8毫克/千克体重的伊维菌素治疗。治疗1周后宰杀羔羊。根据治疗当天每克粪便中的虫卵数以及从每只羔羊体内回收的虫体数量对各治疗组进行比较。莫昔克丁和伊维菌素对清除敏感的捻转血矛线虫均有效，其疗效分别为100%和99.7%。莫昔克丁对耐药株的疗效在0.2毫克/千克和0.4毫克/千克时分别为99.9%和100%，而在分别用0.4毫克/千克体重和0.8毫克/千克体重的伊维菌素治疗的羔羊中，疗效仅分别为38.8%和53.1%。
