Vizoso F J, del Casar J M, Corte M D, García I, Corte M G, Alvarez A, García-Muñiz J L
Servicio de Cirugía General, Hospital de Jove, Avenida Eduardo Castro s/n, 33920 Gijón, Asturias, Spain.
Eur J Surg Oncol. 2004 Apr;30(3):318-24. doi: 10.1016/j.ejso.2003.11.007.
Hyaluronan a high-molecular weight glycosaminoglycan, is considered to be involved in the growth and progression of malignant tumours. The objective of this work was to evaluate the cytosolic hyaluronan content in gastric cancer cells, its possible relationship with clinicopathological tumour parameters and its potential prognostic significance.
Cytosolic hyaluronan levels were examined utilizing immunoenzymatic techniques in 129 patients with gastric cancer. The mean follow-up period for these patients was 28 months.
Cytosolic hyaluronan levels ranged widely in tumours as well as in adjacent mucosal samples (median (range) 2822 (50-24,523) versus 3650 (507-20,782) ng/mg protein). Statistical analysis showed that tumour hyaluronan levels correlated significantly with patient's sex and the presence of lymphatic invasion. In addition, high tumour hyaluronan levels were significantly associated with shorter overall survival period (p<0.05).
Our results suggest that high tumoral cytosolic hyaluronan levels are associated with lesions of unfavorable outcome in gastric cancer patients. Thus, hyaluronan may provide additional prognostic information to that given by other biochemical markers currently used in gastric cancer.
透明质酸是一种高分子量糖胺聚糖，被认为与恶性肿瘤的生长和进展有关。本研究的目的是评估胃癌细胞胞质内透明质酸的含量、其与肿瘤临床病理参数的可能关系及其潜在的预后意义。
采用免疫酶技术检测了129例胃癌患者的胞质透明质酸水平。这些患者的平均随访期为28个月。
肿瘤及相邻黏膜样本中的胞质透明质酸水平差异很大（中位数（范围）分别为2822（50 - 24523）与3650（507 - 20782）ng/mg蛋白质）。统计分析表明，肿瘤透明质酸水平与患者性别及淋巴浸润的存在显著相关。此外，肿瘤透明质酸水平高与总生存期较短显著相关（p<0.05）。
我们的结果表明，肿瘤胞质透明质酸水平高与胃癌患者预后不良的病变有关。因此，透明质酸可能为目前用于胃癌的其他生化标志物提供额外的预后信息。
