Fiehn C, Wermann M, Pezzutto A, Hüfner M, Heilig B
Medizinische Klinik und Poliklinik V, Universität Heidelberg.
Z Rheumatol. 1992 May-Jun;51(3):121-6.
Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a multipotent hematopoietic growth factor, which is mainly produced by T-cells and stromal cells. Beside the stimulating effects on mature granulocytes, it induces the expression of HLA class II-antigen on synovial tissue-cells in patients with rheumatoid arthritis. The concentrations of GM-CSF in the plasma of 87 patients with rheumatoid arthritis, 48 patients with spondyloarthropathy, 17 patients with systemic lupus erythematosus (SLE), and 43 healthy control persons were investigated. We used an immunoradiometric assay (IR-MA) with a detection limit of 30 pg/ml to measure the GM-CSF concentrations in plasma. The GM-CSF levels of 29 patients with severe rheumatoid arthritis (366 +/- 61 pg/ml, p less than 0.05), 58 patients with moderate rheumatoid arthritis (376 +/- 44 pg/ml, p less than 0.0001), and of 17 patients with SLE (256 +/- 41 pg/ml, p less than 0.05) were elevated compared to the control group (174 +/- 18 pg/ml). No significant differences in the mean GM-CSF plasma levels between the patients with spondyloarthropathy (190 +/- 32 pg/ml) and the control group were found. GM-CSF concentrations as high as 1300 pg/ml were detected in the synovial fluids of patients with rheumatoid arthritis. GM-CSF concentrations in the plasma of patients with severe rheumatoid arthritis were correlated with the plasma concentrations of the soluble interleukin-2-receptor (sCD25) (R = +0.53).
粒细胞巨噬细胞集落刺激因子（GM-CSF）是一种多能造血生长因子，主要由T细胞和基质细胞产生。除了对成熟粒细胞有刺激作用外，它还能诱导类风湿性关节炎患者滑膜组织细胞上HLA II类抗原的表达。对87例类风湿性关节炎患者、48例脊柱关节病患者、17例系统性红斑狼疮（SLE）患者和43名健康对照者的血浆中GM-CSF浓度进行了研究。我们使用检测限为30 pg/ml的免疫放射分析（IR-MA）来测量血浆中的GM-CSF浓度。与对照组（174±18 pg/ml）相比，29例重度类风湿性关节炎患者（366±61 pg/ml，p<0.05）、58例中度类风湿性关节炎患者（376±44 pg/ml，p<0.0001）和17例SLE患者（256±41 pg/ml，p<0.05）的GM-CSF水平升高。未发现脊柱关节病患者（190±32 pg/ml）与对照组之间的平均GM-CSF血浆水平有显著差异。在类风湿性关节炎患者的滑液中检测到高达1300 pg/ml的GM-CSF浓度。重度类风湿性关节炎患者血浆中的GM-CSF浓度与可溶性白细胞介素-2受体（sCD25）的血浆浓度相关（R = +0.53）。
