Head Geoffrey A, Burke Sandra L
Neuropharmacology Laboratory, Baker Heart Research Institute, Melbourne, Victoria, Australia.
Ann N Y Acad Sci. 2003 Dec;1009:234-43. doi: 10.1196/annals.1304.029.
An increased role of the sympathetic nervous system has been suggested to be a major contributor to the chronic elevation of BP in renovascular hypertension. We assessed the effects of rilmenidine, a centrally acting antihypertensive imidazoline agent, on BP and renal sympathetic nerve activity (RSNA) in 2K1C renovascular hypertensive conscious rabbits. Rabbits were made hypertensive with a renal clip or were sham-operated and were studied 3 and 6 weeks later. Acute treatment with rilmenidine reduced BP to a greater extent in the hypertensive rabbits. Although rilmenidine reduced the heart rate by the same extent in all groups, rilmenidine produced much less inhibition of RSNA in the hypertensive animals. These studies suggest that the contribution of the sympathetic nervous system is greater in 2K1C hypertension and that imidazoline agents may be beneficial in treating renovascular hypertension.
交感神经系统作用增强被认为是肾血管性高血压患者血压长期升高的主要原因。我们评估了中枢性降压咪唑啉类药物利美尼定对二肾一夹（2K1C）肾血管性高血压清醒兔血压及肾交感神经活性（RSNA）的影响。通过肾动脉夹使兔产生高血压，或进行假手术，3周和6周后进行研究。利美尼定急性治疗使高血压兔血压下降幅度更大。尽管利美尼定在所有组中使心率下降幅度相同，但在高血压动物中，利美尼定对RSNA的抑制作用小得多。这些研究表明，交感神经系统在2K1C高血压中的作用更大，咪唑啉类药物可能对治疗肾血管性高血压有益。
