Andrade Carina A F, Oliveira Lisandra B, Martinez Gizele, Silva Daniela C F, De Luca Laurival A, Menani Jose V
Department of Physiology and Pathology, School of Dentistry, Paulista State University, 14.801-903 Araraquara, SP, Brazil.
Ann N Y Acad Sci. 2003 Dec;1009:262-4. doi: 10.1196/annals.1304.032.
We investigated the participation of central alpha(2)-adrenoceptors and imidazoline receptors in the inhibition of water deprivation-induced water intake in rats. The alpha(2)-adrenoceptor and imidazoline antagonist idazoxan (320 nmol), but not the alpha(2)-adrenoceptor antagonist yohimbine, abolished the antidipsogenic effect of moxonidine (alpha(2)-adrenoceptor and imidazoline agonist, 20 nmol) microinjected into the medial septal area. Yohimbine abolished the antidipsogenic effect of moxonidine intracerebroventricularly. Therefore, central moxonidine may inhibit water intake acting independently on both imidazoline receptors and alpha(2)-adrenoceptors at different forebrain sites.
