含模式识别受体的受体在支架上的组装：一种咪唑啉I(1)受体作用的模型。

Assembly of PRR-containing receptors on scaffolds: a model for imidazoline I(1)-receptor action.

作者信息

Musgrave I F, Dehle F C, Piletz J

机构信息

Department of Clinical and Experimental Pharmacology, University of Adelaide, Adelaide, Australia.

出版信息

Ann N Y Acad Sci. 2003 Dec;1009:413-8. doi: 10.1196/annals.1304.055.

DOI:10.1196/annals.1304.055

PMID:15028620

Abstract

IRAS, a putative clone of the I(1)-imidazoline receptor, possesses a proline-rich region (PRR) motif, which might interact with SH3 regions on tyrosine kinases, and an integrin-binding motif. Receptors with a PRR motif can generally assemble onto multi-element signaling complexes (eg., the beta(3)-receptor on the EGF receptor) and thereby modulate signal transduction. Integrins serve as scaffolds for multi-element signaling complexes, similar to that assembled with the EGF receptor. It is therefore possible that IRAS signals through a complex with other receptors.

摘要

IRAS是I(1)-咪唑啉受体的一个假定克隆体，具有富含脯氨酸区域（PRR）基序，该基序可能与酪氨酸激酶上的SH3区域相互作用，还有一个整合素结合基序。具有PRR基序的受体通常可组装到多元件信号复合物上（例如，表皮生长因子受体上的β(3)-受体），从而调节信号转导。整合素作为多元件信号复合物的支架，类似于与表皮生长因子受体组装的复合物。因此，IRAS有可能通过与其他受体形成的复合物来传递信号。