Floel Agnes, Poeppel David, Buffalo Elizabeth A, Braun Allen, Wu Carolyn W-H, Seo Hyae-Jung, Stefan Katja, Knecht Stefan, Cohen Leonardo G
Human Cortical Physiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health (NIH), Bethesda, MD 20892-1430, USA.
Cereb Cortex. 2004 Apr;14(4):404-9. doi: 10.1093/cercor/bhh002.
Previous work suggested a differential contribution of prefrontal cortex (PFC) to successful encoding depending on the stimulus material. Here, we tested the hypothesis that encoding of words preferentially involves the left PFC, while encoding of nonverbal items (abstract shapes) relies on the right PFC. We used an experimental design that evaluated encoding of both words and abstract shapes in the same healthy volunteers. A transient virtual lesion of the left or the right PFC was elicited with transcranial magnetic stimulation (TMS) while subjects memorized verbal and nonverbal items. We found that encoding of verbal material was disrupted by left PFC stimulation, whereas encoding of nonverbal material was disrupted by right PFC stimulation. These results demonstrate a functionally relevant lateralization of prefrontal contribution for verbal and nonverbal memory encoding.
先前的研究表明，前额叶皮质（PFC）对成功编码的贡献存在差异，这取决于刺激材料。在此，我们测试了以下假设：单词编码优先涉及左侧PFC，而非言语项目（抽象形状）的编码则依赖于右侧PFC。我们采用了一种实验设计，在同一组健康志愿者中评估单词和抽象形状的编码。在受试者记忆言语和非言语项目时，通过经颅磁刺激（TMS）诱发左侧或右侧PFC的短暂虚拟损伤。我们发现，左侧PFC刺激会干扰言语材料的编码，而右侧PFC刺激则会干扰非言语材料的编码。这些结果表明，前额叶对言语和非言语记忆编码的贡献在功能上存在相关的侧化。
