卵巢癌中III型前胶原氨基端前肽。综述。

Aminoterminal propeptide of type III procollagen in ovarian cancer. A review.

作者信息

Risteli L, Risteli J, Puistola U, Tomás C, Zhu G G, Kauppila A

机构信息

Department of Medical Biochemistry, University of Oulu, Finland.

出版信息

Acta Obstet Gynecol Scand Suppl. 1992;155:99-103. doi: 10.1111/j.1600-0412.1992.tb00014.x.

DOI:10.1111/j.1600-0412.1992.tb00014.x

PMID:1502898

Abstract

The concentration of the aminoterminal propeptide of type III procollagen (PIIINP) in serum is a measure of the activity of the metabolism of type III collagen, which is a major constituent of soft connective tissues and of the connective tissue stroma of solid tumours. In advanced ovarian carcinoma, serum PIIINP serves as a tumour-associated antigen, its changes reflecting and preceding changes in the clinical behaviour of the malignancy. Elevated values of serum PIIINP are also observed in endometrial and cervical malignancies, though less frequently than in ovarian tumours. Very high concentrations of PIIINP are found in ovarian carcinoma ascites, suggesting an ongoing fibro-proliferative reaction in the peritoneal cavity as a response to the tumour.

摘要

血清中III型前胶原氨基端前肽（PIIINP）的浓度是III型胶原代谢活性的一个指标，III型胶原是软结缔组织以及实体瘤结缔组织基质的主要成分。在晚期卵巢癌中，血清PIIINP作为一种肿瘤相关抗原，其变化反映并先于恶性肿瘤临床行为的变化。子宫内膜癌和宫颈癌中也可观察到血清PIIINP值升高，不过不如卵巢肿瘤中常见。在卵巢癌腹水中发现PIIINP浓度非常高，提示腹膜腔内存在持续的纤维增生反应，作为对肿瘤的一种反应。