Peng Steven Shinn-Forng, Lee Wang-Tso, Wang Yao Hung, Huang Kou-Mou
Department of Medical Imaging, National Taiwan University Hospital and National Taiwan University College of Medicine, 7 Chung-Shan South Road, Taipei 100 Taiwan.
Pediatr Radiol. 2004 May;34(5):387-92. doi: 10.1007/s00247-004-1162-3. Epub 2004 Mar 17.
In tuberous sclerosis (TS), tubers usually involve the white matter. Diffusion tensor (DT) images are used to demonstrate white-matter tracts.
To determine the changes in DT indices in supratentorial tubers and associated changes in the white-matter tracts adjacent to tubers in patients with TS.
The DT imaging indices, including first, second and third eigenvalues (EVs), apparent diffusion coefficients (ADCs), and fractional anisotropy (FA) in the white-matter lesions of tubers, were assessed in seven patients with TS exhibiting developmental delay and compared with controls.
EV1, EV2, EV3, ADC and FA of the white-matter lesions of tubers were significantly different from contralateral unremarkable regions of the brain and from controls (P<0.05). The number of frontal and parietal tubers was significantly negatively correlated with EV1 of the superior longitudinal fasciculi of TS patients (r=-0.60, P =0.04). In addition, TS patients had significantly larger ADCs in the corona radiata and sagittal stratum than the control subjects. EV3s of the inferior longitudinal fasciculus and sagittal stratum were significantly more increased in the TS patients than in the control subjects.
EV1, EV2, EV3, ADC and FA maps are potential tools for demonstrating cerebral white-matter changes owing to TS.
在结节性硬化症（TS）中，结节通常累及白质。扩散张量（DT）图像用于显示白质束。
确定TS患者幕上结节的DT指数变化以及结节邻近白质束的相关变化。
评估了7例有发育迟缓的TS患者结节白质病变中的DT成像指数，包括第一、第二和第三特征值（EVs）、表观扩散系数（ADCs）和分数各向异性（FA），并与对照组进行比较。
结节白质病变的EV1、EV2、EV3、ADC和FA与对侧正常脑区及对照组有显著差异（P<0.05）。TS患者额叶和顶叶结节的数量与上纵束的EV1显著负相关（r=-0.60，P =0.04）。此外，TS患者放射冠和矢状层的ADC显著大于对照组。TS患者下纵束和矢状层的EV3增加显著多于对照组。
EV1、EV2、EV3、ADC和FA图是显示TS所致脑白质变化的潜在工具。
