Nakazawa M, Koh T, Kani K, Maeda T
Department of Ophthalmology, Shiga University of Medical Science, Ohtsu, Japan.
Nippon Ganka Gakkai Zasshi. 1992 Jul;96(7):892-8.
Serotonergic innervation formed transient dense aggregation in all rat primary sensory areas during early postnatal development. In the normal rat visual cortex, there were three stages in the transient aggregation of serotonin immunoreactive fibers from postnatal day (PND) 2 to 15. Primary aggregates appeared in the subplate prior to the differentiation of layer IV, and moved upward to the lower layer of cortical plate to form secondary aggregates. Secondary aggregation gave rise to ascending fibers on the cortical surface which were roughly grouped in columns (tertiary aggregation). The serotonin fibers of the tertiary aggregates were arranged in a lattice-like pattern in layer I, and were significantly altered either in size of distribution area or column number after monocular or binocular enucleation. These data indicate that the lattice-like pattern of serotonin innervation in neonatal rats may be an evolutionary precursor of the "blobs" seen in the higher primates.
在出生后早期发育阶段，5-羟色胺能神经支配在所有大鼠初级感觉区域形成短暂的密集聚集。在正常大鼠视觉皮层中，从出生后第2天（PND）到15天，5-羟色胺免疫反应性纤维的短暂聚集有三个阶段。初级聚集在IV层分化之前出现在板下层，并向上移动到皮质板的下层形成次级聚集。次级聚集在皮质表面产生向上的纤维，这些纤维大致排列成柱状（三级聚集）。三级聚集的5-羟色胺纤维在I层呈格子状排列，在单眼或双眼摘除后，其分布区域大小或柱数量均发生显著改变。这些数据表明，新生大鼠中5-羟色胺神经支配的格子状模式可能是高等灵长类动物中所见“斑点”的进化前身。
