内毒素在甲基东莨菪碱诱导犊牛瘤胃积食中的作用。
The role of endotoxins in methscopolamine induced ruminal stasis in calves.
作者信息
Aiumlamai S, Kindahl H
机构信息
Department of Obstetrics and Gynaecology, Faculty of Veterinary Medicine, Swedish University of Agricultural Sciences, Uppsala.
出版信息
Acta Vet Scand. 1992;33(2):129-38. doi: 10.1186/BF03547319.
Methscopolamine was used to induce ruminal stasis in calves. Clinical and blood biochemical parameters were studied to judge the possible role of gastro-intestinal endotoxins from Gram-negative bacteria. Two trials were carried out where one injection of 100 mg and 3 consecutive injections of 70 mg of methscopolamine were administered. The animals showed signs of ruminal stasis. General clinical signs and changes in blood biochemical parameters were similar to what is found in endotoxaemia or in induced ruminal acidosis. Relevant parameters such as prostaglandin F2 alpha metabolite, endotoxin, iron, zinc, calcium and glutamate dehydrogenase changed significantly indicating exposure of endotoxins.
甲基东莨菪碱被用于诱导犊牛瘤胃积食。研究了临床和血液生化参数，以判断革兰氏阴性菌产生的胃肠道内毒素可能发挥的作用。进行了两项试验，分别注射100毫克甲基东莨菪碱一次和连续注射70毫克甲基东莨菪碱三次。动物出现了瘤胃积食的症状。一般临床症状和血液生化参数的变化与内毒素血症或诱导性瘤胃酸中毒中发现的情况相似。前列腺素F2α代谢物、内毒素、铁、锌、钙和谷氨酸脱氢酶等相关参数发生了显著变化，表明存在内毒素暴露。
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