内毒素在犊牛诱发性瘤胃酸中毒中的作用。
The role of endotoxins in induced ruminal acidosis in calves.
作者信息
Aiumlamai S, Kindahl H, Fredriksson G, Edqvist L E, Kulander L, Eriksson O
机构信息
Department of Obstetrics and Gynaecology, Faculty of Veterinary Medicine, Swedish University of Agricultural Sciences, Uppsala.
出版信息
Acta Vet Scand. 1992;33(2):117-27. doi: 10.1186/BF03547318.
Experimentally induced ruminal acidosis was carried out in 4 calves to investigate the possibility of resorption of endotoxins from Gram negative bacteria originating from the gastro-intestinal tract. The ruminal acidosis was induced by overfeeding of oats and the effect was evaluated by clinical and blood biochemical changes. Blood samples were collected every 2 h for 60 h before and after experimental feeding. The animals showed signs of ruminal acidosis and also the clinical and blood biochemical changes were similar to those seen after experimental endotoxaemia. However, although being less dramatic the changes in many relevant parameters such as an increase in prostaglandin F metabolite levels, body temperature, endotoxins and a decrease in iron indicate that an endotoxaemic state had occurred. The results of the present study show that ruminal acidosis/stasis is linked to resorption of endotoxins from the gastro-intestinal tract causing endotoxaemia/endotoxicosis.
对4头犊牛进行了实验性瘤胃酸中毒，以研究胃肠道革兰氏阴性菌产生的内毒素重吸收的可能性。通过过量饲喂燕麦诱导瘤胃酸中毒，并通过临床和血液生化变化评估效果。在实验性饲喂前后60小时内，每2小时采集一次血样。动物表现出瘤胃酸中毒的症状，临床和血液生化变化也与实验性内毒素血症后观察到的相似。然而，尽管许多相关参数的变化不那么显著，如前列腺素F代谢物水平升高、体温、内毒素升高以及铁含量降低，但表明已经发生了内毒素血症状态。本研究结果表明，瘤胃酸中毒/淤滞与胃肠道内毒素重吸收有关，导致内毒素血症/内毒素中毒。
Zotero 插件