Higgins John P, Higgins Johanna A, Higgins Patricia M, Ahuja Samir, Higgins Daniel L
Harvard Medical School, Brigham and Women's Hospital, Cardiology Section, 4C108, VA Boston Healthcare System, 1400 VFW Parkway, Boston, MA 02132, USA.
Expert Rev Cardiovasc Ther. 2003 Sep;1(3):367-84. doi: 10.1586/14779072.1.3.367.
Chlamydia pneumoniae (Cp) infection in early life may accelerate atherosclerosis over ensuing decades, leading to cardiovascular complications. Cp promotes endothelial dysfunction and may modulate inflammation underlying atherosclerosis. It represents a biologically plausible candidate for the causation of atherosclerosis. Other infections simultaneously occurring with Cp may result in a synergistic effect to promote atherosclerosis. Studies on the treatment of Cp with antibiotics indicates decreased rates of infection, modulation of inflammation and in some settings, fewer cardiovascular complications.
肺炎衣原体（Cp）在生命早期的感染可能会在随后几十年加速动脉粥样硬化，导致心血管并发症。Cp会促进内皮功能障碍，并可能调节动脉粥样硬化潜在的炎症反应。它是动脉粥样硬化病因学中一个生物学上合理的候选因素。与Cp同时发生的其他感染可能会产生协同效应，促进动脉粥样硬化。用抗生素治疗Cp的研究表明感染率降低、炎症得到调节，在某些情况下，心血管并发症也会减少。
