Fortuño María A, López Natalia, González Arantxa, Díez Javier
Division of Cardiovascular Pathophysiology, School of Medicine, University of Navarra, Pamplona, Spain.
Expert Rev Cardiovasc Ther. 2003 Jul;1(2):293-307. doi: 10.1586/14779072.1.2.293.
The balance between cell death and cell survival is a tightly controlled process, especially in terminally differentiated cells, such as the cardiomyocyte. Accumulating data support a role for cardiomyocyte apoptosis in the development of several cardiac diseases, including the transition from hypertensive compensatory hypertrophy to heart failure. This review briefly summarizes the status of the knowledge regarding the death-survival balance of cardiomyocytes in the context of hypertensive heart disease. Several molecular and cellular aspects as well as the most relevant pathophysiological implications are presented. Moreover, diagnosis tools under development and the possibilities for pharmacological intervention are also examined.
细胞死亡与细胞存活之间的平衡是一个受到严格调控的过程，在终末分化细胞（如心肌细胞）中尤为如此。越来越多的数据支持心肌细胞凋亡在多种心脏疾病的发展过程中发挥作用，包括从高血压代偿性肥大向心力衰竭的转变。本综述简要总结了在高血压性心脏病背景下，关于心肌细胞死亡 - 存活平衡的知识现状。介绍了几个分子和细胞方面的内容以及最相关的病理生理意义。此外，还研究了正在开发的诊断工具以及药物干预的可能性。
