Ruilope Luis M, Segura Julián, Campo Carlos, Rodicio José L
Unidad de Hipertensión, Hospital 12 de Octubre, Madrid, Spain.
Expert Rev Cardiovasc Ther. 2003 Jul;1(2):309-15. doi: 10.1586/14779072.1.2.309.
The kidney plays a relevant role in the origin of essential hypertension in humans, and it suffers the consequences of sustained elevated blood pressure in the absence of therapy. Recently, a relevant prevalence of mild renal insufficiency both in general population than in hypertensive patients has been described. A direct relationship seems to exist between the level of cardiovascular risk and the prevalence of the renal disorder, whether this is detected as an elevation in serum creatinine or as a diminution of estimated creatinine clearance. This renal function impairment is a strong predictor of cardiovascular risk in patients with chronic heart failure and following myocardial infarction. Prevention of renal and cardiovascular damage in these patients will be one of the most relevant tasks in the future. The aim of this short review is to discuss the evidence in favor of a relevant prevalence of mild renal insufficiency in hypertensive patients, as well as the association of this disorder with a very significant increment in global cardiovascular risk.
肾脏在人类原发性高血压的发病中起着重要作用，并且在未接受治疗的情况下会承受持续高血压带来的后果。最近，已报道轻度肾功能不全在普通人群和高血压患者中的患病率都很高。心血管风险水平与肾脏疾病的患病率之间似乎存在直接关系，无论这种肾脏疾病是通过血清肌酐升高还是估算的肌酐清除率降低来检测。这种肾功能损害是慢性心力衰竭患者和心肌梗死后心血管风险的有力预测指标。预防这些患者的肾脏和心血管损害将是未来最重要的任务之一。这篇简短综述的目的是讨论支持高血压患者中轻度肾功能不全患病率较高的证据，以及这种疾病与全球心血管风险显著增加之间的关联。
