Ip W K, To Y F, Cheng S K, Lau Y L
Department of Paediatrics and Adolescent Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong, China.
Scand J Immunol. 2004 Mar;59(3):310-4. doi: 10.1111/j.0300-9475.2004.01392.x.
Mannose-binding lectin (MBL) is an acute-phase serum protein, and its inherited deficiency has been shown to predispose to infections. The developmental profile of serum MBL in preterm infants has been demonstrated previously. To determine the profiles of serum MBL levels and mbl2 polymorphisms over age and genders in an adult population, samples from 689 southern Chinese (age range 16-57 years; 382 males and 307 females) were studied using enzyme-linked immunosorbent assay and high-throughput genotyping of mbl2. Serum MBL levels maintained within a narrow range from age groups of 16-20 years old to 31-40 years old (mean of 2050-2160 micro g/l) and declined to a mean of 1466 micro g/l in the last age group 41-57 years old. No significant differences were found in the distributions of mbl2 haplotypes (YA, XA and YB) among all these age groups. Between gender groups, no significant imbalance of MBL profile in terms of serum MBL levels and distribution of mbl2 haplotypes was found. Results suggest an important role of circulating MBL in first-line host defence because MBL maintains at fairly constant levels after childhood and no gender influence on the MBL profile.
甘露糖结合凝集素（MBL）是一种急性期血清蛋白，其遗传性缺乏已被证明易导致感染。此前已证明了早产儿血清MBL的发育情况。为了确定成年人群中血清MBL水平和mbl2基因多态性随年龄和性别的变化情况，我们使用酶联免疫吸附测定法和mbl2的高通量基因分型技术，对689名中国南方人（年龄范围16 - 57岁；男性382名，女性307名）的样本进行了研究。血清MBL水平在16 - 20岁至31 - 40岁年龄组内保持在较窄范围内（平均为2050 - 2160微克/升），在最后一个年龄组41 - 57岁时降至平均1466微克/升。在所有这些年龄组中，mbl2单倍型（YA、XA和YB）的分布没有显著差异。在性别组之间，未发现血清MBL水平和mbl2单倍型分布方面的MBL情况存在显著失衡。结果表明循环MBL在一线宿主防御中起重要作用，因为MBL在儿童期后维持在相当恒定的水平，且性别对MBL情况没有影响。
