Mott G E, Jackson E M, McMahan C A
Department of Pathology, University of Texas Health Science Center, San Antonio 78284-7750.
Am J Clin Nutr. 1992 Sep;56(3):511-6. doi: 10.1093/ajcn/56.3.511.
We measured the effects of dietary cholesterol (0.24 vs 0.0024 mg/kJ), type of dietary fat [saturated, a ratio of polyunsaturated to saturated fatty acids (P:S) of 0.37, vs unsaturated (P:S of 2.2)], and sex on biliary lipid and bile acid conjugate composition of 80 adult pedigreed baboons. From these data we calculated the bile cholesterol saturation index and the bile acid hydrophobicity index. Dietary cholesterol significantly increased the bile cholesterol concentration by 25% and the bile cholesterol saturation index by 15%, but did not significantly affect the bile acid conjugate composition or the bile acid hydrophobicity index. Diets high in saturated fatty acid compared with unsaturated fatty acid significantly decreased the bile cholesterol concentrations by 26% and the saturation index by 23%. Saturated fatty acid also decreased the proportion of hydrophobic bile acids and lowered the bile hydrophobicity index. Male baboons had a higher cholesterol saturation index and a lower hydrophobicity index than females. Dietary cholesterol and saturated fatty acid independently influence the bile lipid composition and the cholesterol saturation index.
我们测定了膳食胆固醇（0.24 与 0.0024 毫克/千焦）、膳食脂肪类型[饱和脂肪，多不饱和脂肪酸与饱和脂肪酸之比（P:S）为 0.37，与不饱和脂肪（P:S 为 2.2）]以及性别对 80 只成年纯种狒狒胆汁脂质和胆汁酸结合物组成的影响。根据这些数据，我们计算了胆汁胆固醇饱和指数和胆汁酸疏水性指数。膳食胆固醇使胆汁胆固醇浓度显著升高 25%，胆汁胆固醇饱和指数升高 15%，但对胆汁酸结合物组成或胆汁酸疏水性指数无显著影响。与不饱和脂肪酸相比，富含饱和脂肪酸的饮食使胆汁胆固醇浓度显著降低 26%，饱和指数降低 23%。饱和脂肪酸还降低了疏水性胆汁酸的比例，并降低了胆汁疏水性指数。雄性狒狒的胆固醇饱和指数高于雌性，疏水性指数低于雌性。膳食胆固醇和饱和脂肪酸独立影响胆汁脂质组成和胆固醇饱和指数。
