黏膜HIV感染的免疫生物学及新一代黏膜艾滋病疫苗的研发基础
Immunobiology of mucosal HIV infection and the basis for development of a new generation of mucosal AIDS vaccines.
作者信息
Belyakov Igor M, Berzofsky Jay A
机构信息
Vaccine Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
出版信息
Immunity. 2004 Mar;20(3):247-53. doi: 10.1016/s1074-7613(04)00053-6.
Abstract
Mucosal tissues are the primary site of natural HIV transmission and a major reservoir for HIV replication. Targeting immune responses to the mucosal entry site before viral dissemination could protect and also clear viral reservoirs. Recent understanding of mucosal HIV transmission and of chemokines and integrins in mucosal trafficking can aid design of new strategies to enhance AIDS vaccine efficacy.
摘要
黏膜组织是HIV自然传播的主要部位，也是HIV复制的主要储存库。在病毒传播之前针对黏膜进入部位的免疫反应可以起到保护作用，还能清除病毒储存库。最近对黏膜HIV传播以及黏膜转运中趋化因子和整合素的了解有助于设计提高艾滋病疫苗效力的新策略。
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