通过脑磁图检测白化病患者视网膜神经纤维错路的新方法。

New method for detecting misrouted retinofugal fibers in humans with albinism by magnetoencephalography.

作者信息

Ohde Hisao, Shinoda Kei, Nishiyama Takatsune, Kado Hisashi, Haruta Yasuhiro, Mashima Yukihiko, Oguchi Yoshihisa

机构信息

Department of Ophthalmology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku, Tokyo 160-8582, Japan.

出版信息

Vision Res. 2004 May;44(10):1033-8. doi: 10.1016/j.visres.2003.12.005.

DOI:10.1016/j.visres.2003.12.005

PMID:15031097

Abstract

In humans with albinism, a large percentage of the ganglion cell axons from the temporal retina decussate abnormally in the chiasm and synapse in the contralateral LGN. The aim of this study was to determine whether the misrouting of the optic fibers can be detected by magnetoencephalography (MEG). Visually evoked magnetic fields (VEFs) were recorded from three patients with albinism. After monocular stimulation, the isofield contour maps of the VEFs showed a single current dipole pattern over the contralateral hemisphere in patients with albinism. These results clearly illustrated the reduced uncrossed retinofugal pathway of patients with albinism.

摘要

在患有白化病的人类中，来自颞侧视网膜的大部分神经节细胞轴突在视交叉处异常交叉，并在对侧外侧膝状体核（LGN）中形成突触。本研究的目的是确定是否可以通过脑磁图（MEG）检测到视神经纤维的错误布线。记录了三名白化病患者的视觉诱发电场（VEF）。在单眼刺激后，白化病患者的VEF等场轮廓图显示对侧半球上有单个电流偶极子模式。这些结果清楚地说明了白化病患者未交叉的视网膜神经通路减少。