G-463A髓过氧化物酶基因多态性与MPO-ANCA相关性血管炎无关联。
No association of G-463A myeloperoxidase gene polymorphism with MPO-ANCA-associated vasculitis.
作者信息
Fiebeler Anette, Borgmann Stefan, Woywodt Alexander, Haller Hermann, Haubitz Marion
机构信息
Department of Nephrology, Medical School Hannover, D-30623 Hannover, Germany.
出版信息
Nephrol Dial Transplant. 2004 Apr;19(4):969-71. doi: 10.1093/ndt/gfh025.
BACKGROUND
The activation of neutrophils and monocytes by ANCA, resulting in the release of reactive oxygen species and proteases like myeloperoxidase (MPO), is essential to the pathogenesis of ANCA-associated vasculitis. As the A allele of the G-463A MPO gene polymorphism is associated with diminished activity of MPO, it is conceivable that the presence of this allele protects against MPO-ANCA-associated vasculitis.
METHODS
Allelic frequencies of the G-463A polymorphism were studied in 119 ANCA-associated vasculitis patients, 48 with MPO-ANCA and 71 with proteinase 3 (PR3)-ANCA.
RESULTS
Allelic frequencies of MPO G-463A promoter polymorphism did not differ between MPO-ANCA- and PR3-ANCA-associated vasculitis patients. Moreover, allelic distribution was similar to that of the normal population.
CONCLUSIONS
The data suggest that G-463A polymorphism does not seem to contribute to either MPO-ANCA- or PR3-ANCA-associated vasculitis formation.
背景
抗中性粒细胞胞浆抗体（ANCA）激活中性粒细胞和单核细胞，导致活性氧物质和诸如髓过氧化物酶（MPO）等蛋白酶的释放，这对抗中性粒细胞胞浆抗体相关性血管炎的发病机制至关重要。由于MPO基因G-463A多态性的A等位基因与MPO活性降低有关，可以推测该等位基因的存在可预防MPO-ANCA相关性血管炎。
方法
在119例抗中性粒细胞胞浆抗体相关性血管炎患者中研究G-463A多态性的等位基因频率，其中48例为MPO-ANCA阳性，71例为蛋白酶3（PR3）-ANCA阳性。
结果
MPO-ANCA相关性血管炎患者与PR3-ANCA相关性血管炎患者之间，MPO G-463A启动子多态性的等位基因频率没有差异。此外，等位基因分布与正常人群相似。
结论
数据表明，G-463A多态性似乎与MPO-ANCA或PR3-ANCA相关性血管炎的形成均无关。
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