Geisler J P, Tammela J E, Manahan K J, Geisler H E, Miller G A, Zhou Z, Wiemann M C
Division of Gynecologic Oncology, St. Vincent Hospitals Indianapolis, Indiana 46260, USA.
Eur J Gynaecol Oncol. 2004;25(2):165-8.
Heat shock protein 27 (HSP27) is produced in response to pathophysiologic stress in animal cells. The authors have previously shown that HSP27 is an independent prognostic indicator in patients with ovarian carcinoma. The present study was performed to see whether HSP27 remained an independent prognostic indicator with longer follow-up.
One hundred and three consecutive patients with epithelial ovarian carcinoma were studied. Slides were prepared from fresh tissue. HPS27 staining was performed as previously described. Patient records were examined for FIGO stage, grade, histology, level of cytoreduction and survival.
One hundred and three patients were followed for a mean of 60 months. Twenty patients had FIGO Stage I disease, four Stage II, 59 Stage III, and 20 Stage IV. Immunohistochemical (IHC) staining for HSP27 was not related to histologic grade, level of cytoreduction or histologic subtype. A statistically significant decrease in HSP27 staining was found to correlate with increased FIGO stage (p = 0.008). Using cox-regression analysis, HSP27 staining (p = 0.025), stage (p = 0.0012), and level of cytoreduction (p < 0.0001) were independent predictors of survival in these patients.
Cox-regression analysis found HSP27 to be an independent indicator of prognosis and survival in patients with ovarian carcinoma who had longer follow-up. Decreased HSP27 staining was related to decreased survival. This study confirms the authors' earlier report on the importance of HSP27 as a prognostic indicator in ovarian carcinoma.
热休克蛋白27（HSP27）是动物细胞在病理生理应激反应时产生的。作者之前已表明HSP27是卵巢癌患者的一个独立预后指标。本研究旨在观察随着随访时间延长HSP27是否仍是一个独立预后指标。
对103例连续的上皮性卵巢癌患者进行研究。从新鲜组织制备玻片。按照之前描述的方法进行HPS27染色。检查患者记录以了解国际妇产科联盟（FIGO）分期、分级、组织学类型、肿瘤细胞减灭程度及生存情况。
103例患者平均随访60个月。20例患者为FIGO I期疾病，4例为II期，59例为III期，20例为IV期。HSP27的免疫组织化学（IHC）染色与组织学分级、肿瘤细胞减灭程度或组织学亚型无关。发现HSP27染色的统计学显著降低与FIGO分期增加相关（p = 0.008）。使用Cox回归分析，HSP27染色（p = 0.025）、分期（p = 0.0012）和肿瘤细胞减灭程度（p < 0.0001）是这些患者生存的独立预测因素。
Cox回归分析发现HSP27是随访时间更长的卵巢癌患者预后和生存的独立指标。HSP27染色降低与生存率降低相关。本研究证实了作者早期关于HSP27作为卵巢癌预后指标重要性的报告。
