Montella F, Giana M, Vigone A, Surico D, Surico N
Department of Obstetrics and Gynaecology, Piemonte Orientale University, Novara, Italy.
Eur J Gynaecol Oncol. 2004;25(2):253-4.
A case of solitary angiomyofibroblastoma of the vulva in a 16-year-old woman was examined by histology and immunohistochemistry. Microscopic examination of the tumor revealed typical features of a mesenchymal neoplasm, composed of bundle spindle cells with low cellular density, rich in collagen fibers and thin-walled blood vessels. Immunohistochemistry revealed immunoreactivity for progesterone receptor, CD34, desmin and vimentin, tumor cells expressing positivity, but not for estrogen receptors. The stains for the muscle-specific actin and S-100 were negative. These results were mostly consistent with those of previous reports and suggest that the tumors cells were derived from primitive mesenchymal cells which occur normally in this region and show the potential for diverse lines of myoid differentiation.
对一名16岁女性外阴孤立性血管肌纤维母细胞瘤病例进行了组织学和免疫组织化学检查。肿瘤的显微镜检查显示为间叶性肿瘤的典型特征，由细胞密度低的束状梭形细胞组成，富含胶原纤维和薄壁血管。免疫组织化学显示孕激素受体、CD34、结蛋白和波形蛋白呈免疫反应性，肿瘤细胞呈阳性表达，但雌激素受体呈阴性。肌肉特异性肌动蛋白和S-100染色均为阴性。这些结果与先前报道的结果基本一致，提示肿瘤细胞来源于该区域正常存在的原始间叶细胞，并显示出多种肌样分化谱系的潜能。
