Pestka Sidney, Krause Christopher D, Sarkar Devanand, Walter Mark R, Shi Yufang, Fisher Paul B
Department of Molecular Genetics, Microbiology, and Immunology, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, Piscataway, New Jersey 08854, USA.
Annu Rev Immunol. 2004;22:929-79. doi: 10.1146/annurev.immunol.22.012703.104622.
The Class 2 alpha-helical cytokines consist of interleukin-10 (IL-10), IL-19, IL-20, IL-22, IL-24 (Mda-7), and IL-26, interferons (IFN-alpha, -beta, -epsilon, -kappa, -omega, -delta, -tau, and -gamma) and interferon-like molecules (limitin, IL-28A, IL-28B, and IL-29). The interaction of these cytokines with their specific receptor molecules initiates a broad and varied array of signals that induce cellular antiviral states, modulate inflammatory responses, inhibit or stimulate cell growth, produce or inhibit apoptosis, and affect many immune mechanisms. The information derived from crystal structures and molecular evolution has led to progress in the analysis of the molecular mechanisms initiating their biological activities. These cytokines have significant roles in a variety of pathophysiological processes as well as in regulation of the immune system. Further investigation of these critical intercellular signaling molecules will provide important information to enable these proteins to be used more extensively in therapy for a variety of diseases.
2类α-螺旋细胞因子包括白细胞介素-10（IL-10）、IL-19、IL-20、IL-22、IL-24（黑色素瘤分化相关基因7）和IL-26、干扰素（IFN-α、-β、-ε、-κ、-ω、-δ、-τ和-γ）以及干扰素样分子（限制素、IL-28A、IL-28B和IL-29）。这些细胞因子与其特异性受体分子的相互作用引发了一系列广泛而多样的信号，这些信号可诱导细胞抗病毒状态、调节炎症反应、抑制或刺激细胞生长、产生或抑制细胞凋亡，并影响多种免疫机制。来自晶体结构和分子进化的信息推动了对启动其生物学活性的分子机制分析的进展。这些细胞因子在多种病理生理过程以及免疫系统调节中发挥着重要作用。对这些关键的细胞间信号分子的进一步研究将提供重要信息，使这些蛋白质能够更广泛地用于多种疾病的治疗。
