Makrigiannakis A, Zoumakis E, Kalantaridou S, Chrousos G, Gravanis A
Department of Ob/Gyn Medical School, University of Crete, Heraklion 71110, Greece.
Curr Drug Targets Immune Endocr Metabol Disord. 2004 Mar;4(1):75-8. doi: 10.2174/1568008043339992.
The hypothalamic neuropeptide corticotropin-releasing hormone (CRH) is produced by several tissues of the female reproductive system. It is also secreted at inflammatory sites and possesses potent pro-inflammatory properties influencing both innate and acquired immune processes. Uterine CRH participates in local immune early pregnancy phenomena, such as decidualization of endometrial strom a and protection of the fetus from maternal immune system. This is maintained through induction of the expression of apoptotic FasL on invasive extravillous trophoblast and maternal decidual cells at the fetal-maternal interface. Furthermore, CRH increases apoptosis of activated T lymphocytes through FasL induction participating in the process of implantation and early pregnancy. Female rats treated with the non-peptidic CRH receptor 1 (CRHR1) specific antagonist antalarmin, in the first 6 days of gestation, have undergone a decrease of endometrial implantation sites and live embryos and markedly diminished endometrial FasL expression.
下丘脑神经肽促肾上腺皮质激素释放激素（CRH）由女性生殖系统的多个组织产生。它也在炎症部位分泌，并具有强大的促炎特性，影响先天性和获得性免疫过程。子宫CRH参与局部免疫早期妊娠现象，如子宫内膜基质蜕膜化以及保护胎儿免受母体免疫系统攻击。这是通过诱导侵袭性绒毛外滋养层和胎儿-母体界面处母体蜕膜细胞上凋亡性FasL的表达来维持的。此外，CRH通过诱导FasL增加活化T淋巴细胞的凋亡，参与着床和早期妊娠过程。在妊娠的前6天用非肽类CRH受体1（CRHR1）特异性拮抗剂安他乐明处理的雌性大鼠，其子宫内膜着床部位和活胚胎数量减少，子宫内膜FasL表达明显降低。
