ter Haar E, Walters W P, Pazhanisamy S, Taslimi P, Pierce A C, Bemis G W, Salituro F G, Harbeson S L
Vertex Pharmaceuticals, Inc., 130 Waverly Street, Cambridge, Massachusetts 02139, USA.
Mini Rev Med Chem. 2004 Mar;4(3):235-53. doi: 10.2174/1389557043487367.
Chemogenomics is a gene family-based approach to drug discovery and target validation. This review will summarize the application of this interdisciplinary approach to the protein kinases of the human genome with emphasis upon the synergies and efficiencies to be gained. Specific examples from the SAPK-family will be discussed.
化学基因组学是一种基于基因家族的药物发现和靶点验证方法。本综述将总结这种跨学科方法在人类基因组蛋白激酶中的应用，重点关注其协同作用和效率提升。将讨论丝裂原活化蛋白激酶家族的具体实例。
