Symons M, Bell K
Department of Physiology and Pharmacology, University of Queensland, St Lucia, Australia.
Anim Genet. 1992;23(4):315-24. doi: 10.1111/j.1365-2052.1992.tb00153.x.
A canine blood group antigen, QN, which was detected by a naturally occurring alloantibody in the antiglobulin test, was shown to be antigenically related to the human A and cattle J antigens by absorption experiments. Family studies supported a dominant mode of inheritance with the gene controlling the production of QN being dominant to the gene responsible for its absence. Frequencies of the QN and Tr antigens and serological data strongly suggested that the two antigens are identical. Two canine plasma alkaline phosphatase variants, F and S, were detected by starch gel electrophoresis, pH 8.65. Assuming genetic control of two codominant alleles, ALPF and ALPS, the distributions of types in families differed significantly from expectation. A relationship between the ALP and Tr(QN) systems was demonstrated with Tr-positive animals having a significant deficiency of S alkaline phosphatase types.
一种犬类血型抗原QN，在抗球蛋白试验中由一种天然存在的同种抗体检测到，通过吸收实验表明它在抗原性上与人类A抗原和牛J抗原相关。家系研究支持显性遗传模式，控制QN产生的基因对导致其缺失的基因呈显性。QN和Tr抗原的频率以及血清学数据强烈表明这两种抗原是相同的。通过pH 8.65的淀粉凝胶电泳检测到两种犬血浆碱性磷酸酶变体F和S。假设由两个共显性等位基因ALPF和ALPS进行基因控制，家系中各类型的分布与预期有显著差异。在Tr阳性动物中S型碱性磷酸酶明显缺乏，证明了碱性磷酸酶（ALP）和Tr（QN）系统之间的关系。
