Lee Taeseung, Sumpio Bauer E
Department of Surgery, Section of Vascular Surgery, Yale University School of Medicine, PO Box 208062, FMB 137, New Haven, CT 06520, USA.
Biotechnol Appl Biochem. 2004 Apr;39(Pt 2):129-39. doi: 10.1042/BA20030104.
Phosphorylation of tyrosine or serine/threonine residues of intracellular proteins is a reversible and dynamic process which is essential in controlling cellular growth, migration and survival. The phosphorylation states of numerous intermediary signalling proteins are governed by the opposing activities of protein kinases and phosphatases. Abnormal phosphorylation states have been linked with many human diseases, including cancer, diabetes, hypertension and cardiac hypertrophy. Recently, several reports have described the role of phosphatases in regulating critical cellular functions and signalling pathways in vascular cells. This Review will focus on the significance of several of these phosphatases and present information on the role of protein phosphatase type 2a in endothelial cells exposed to haemodynamic forces.
细胞内蛋白质酪氨酸或丝氨酸/苏氨酸残基的磷酸化是一个可逆的动态过程，对控制细胞生长、迁移和存活至关重要。众多中间信号蛋白的磷酸化状态由蛋白激酶和磷酸酶的相反活性所调控。异常的磷酸化状态与许多人类疾病相关，包括癌症、糖尿病、高血压和心脏肥大。最近，有几份报告描述了磷酸酶在调节血管细胞关键细胞功能和信号通路中的作用。本综述将聚焦于其中几种磷酸酶的重要性，并介绍2a型蛋白磷酸酶在暴露于血流动力学力的内皮细胞中的作用信息。
