Hanson Ronald L, Kant Joydeep, Patel Ramesh N
Process Research and Development, Bristol-Myers Squibb Pharmaceutical Research Institute, 1 Squibb Drive, New Brunswick, NJ 08903, USA.
Biotechnol Appl Biochem. 2004 Apr;39(Pt 2):209-14. doi: 10.1042/BA20030093.
6-alpha-Hydroxy-7-deoxy-10-deacetylbaccatin-III is an intermediate that is potentially useful for synthesis of analogues of paclitaxel. Screening of microbial strains identified an enzyme activity in Nocardioides luteus SC 13912 (A.T.C.C. 55426) which converted 7-deoxy-10-deacetylbaccatin-III into 6-hydroxy-7-deoxy-10-deacetylbaccatin-III with a maximum yield of 44%.
