Duran Marta, Laporte Joan-Ramon, Capellà Dolors
Fundació Institut Català de Farmacologia, Hospital Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, España.
Med Clin (Barc). 2004 Mar 20;122(10):390-8. doi: 10.1016/s0025-7753(04)74251-7.
Growing basic research in recent years led to the discovery of the endocannabinoid system with a central role in neurobiology. New evidence suggests a therapeutic potential of cannabinoids in cancer chemotherapy-induced nausea and vomiting as well as in pain, spasticity and other symptoms in multiple sclerosis and movement disorders. Results of large randomized clinical trials of oral and sublingual Cannabis extracts will be known soon and there will be definitive answers to whether Cannabis has any therapeutic potential. Although the immediate future may lie in plant-based medicines, new targets for cannabinoid therapy focuses on the development of endocannabinoid degradation inhibitors which may offer site selectivity not afforded by cannabinoid receptor agonists.
近年来基础研究的不断发展促成了内源性大麻素系统的发现，该系统在神经生物学中起着核心作用。新证据表明，大麻素在癌症化疗引起的恶心和呕吐以及多发性硬化症和运动障碍的疼痛、痉挛及其他症状方面具有治疗潜力。口服和舌下含服大麻提取物的大型随机临床试验结果即将揭晓，大麻是否具有任何治疗潜力也将有明确答案。尽管近期的发展方向可能是基于植物的药物，但大麻素治疗的新靶点集中在内源性大麻素降解抑制剂的研发上，这类抑制剂可能具有大麻素受体激动剂所没有的位点选择性。
