Gaudreau Geneviève-Anne, Plourde Victor
Neurobiology and Digestive Motility Laboratory, Hopital St-Luc, CHUM Research Center, University of Montreal, 264 East René-Lévesque, Montréal, Que., Canada H2X 1P1.
Behav Brain Res. 2004 Apr 2;150(1-2):185-9. doi: 10.1016/j.bbr.2003.07.004.
N-Methyl-d-aspartate (NMDA) is known to be involved in the transmission of nociceptive information. In the present study, we investigated the effect of peripheral and central NMDA receptor antagonist MK-801 in visceral hypersensitivity. In an animal model of colorectal distension (CRD), administration of both intrathecal MK-801 (1.5 nmol) and intraperitoneal MK-801 (0.15 mg/kg) completely abolished the CRD-induced visceral hypersensitivity of noxious and innocuous stimuli. Thus, the results from this experiment demonstrate the efficacy of MK-801 in blocking the visceral hypersensitivity mediated by central and peripheral mechanisms.
已知N-甲基-D-天冬氨酸（NMDA）参与伤害性信息的传递。在本研究中，我们研究了外周和中枢NMDA受体拮抗剂MK-801对内脏高敏感性的影响。在结直肠扩张（CRD）动物模型中，鞘内注射MK-801（1.5纳摩尔）和腹腔注射MK-801（0.15毫克/千克）均完全消除了CRD诱导的有害和无害刺激引起的内脏高敏感性。因此，本实验结果证明了MK-801在阻断由中枢和外周机制介导的内脏高敏感性方面的有效性。
