抗氧化剂对细胞凋亡的挽救作用发生在谷胱甘肽外排的下游。
Rescue of cells from apoptosis by antioxidants occurs downstream from GSH extrusion.
作者信息
Liuzzi Francesca, Fanelli Claudia, Ciriolo Maria Rosa, Cerella Claudia, D'Alessio Maria, Denicola Milena, Magrini Andrea, Bergamaschi Antonio, Ghibelli Lina
机构信息
Dipartimento di Biologia, Cattedra Medicina del Lavoro, Universita di Roma Tor Vergata, 00133 Rome, Italy.
出版信息
Ann N Y Acad Sci. 2003 Dec;1010:441-5. doi: 10.1196/annals.1299.080.
Antioxidants-that is, scavengers of free radicals and anaerobic conditions (5%CO(2), 95% N(2))-protect monocytic U937 cells from damage-induced apoptosis. Antioxidants rescue the cells acting on the apoptotic pathway at a step downstream from gluthatione extrusion. Reducing agents, such as DTT, also reduce stress-induced apoptosis. Thus, apoptotic GSH extrusion triggers the downstream events of apoptosis by leaving cells unprotected against thiol\s oxidation and radical production.
抗氧化剂，即自由基清除剂以及在无氧条件下（5%二氧化碳，95%氮气），可保护单核细胞U937细胞免受损伤诱导的凋亡。抗氧化剂在谷胱甘肽排出下游的凋亡途径步骤中发挥作用来拯救细胞。还原剂，如二硫苏糖醇，也可减少应激诱导的凋亡。因此，凋亡性谷胱甘肽排出通过使细胞无法抵御硫醇氧化和自由基产生，从而触发凋亡的下游事件。
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