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细胞色素c、谷胱甘肽以及氧化还原电位在细胞凋亡中的可能作用。

Cytochrome c, glutathione, and the possible role of redox potentials in apoptosis.

作者信息

Hancock John T, Desikan Radhika, Neill Steven J

机构信息

Centre for Research in Plant Science, University of the West of England, Bristol, Coldharbour Lane, Bristol, BS16 1QY, United Kingdom.

出版信息

Ann N Y Acad Sci. 2003 Dec;1010:446-8. doi: 10.1196/annals.1299.081.

DOI:10.1196/annals.1299.081
PMID:15033768
Abstract

The redox environment of the cell is now thought to be extremely important to control the activity of many proteins. During apoptosis, the intracellular redox potential (E(h)) becomes more positive, with possible consequences for the mechanisms of apoptosis. Glutathione and cytochrome c might both influence and be influenced by the cellular redox environment and therefore be important in the progression of apoptosis.

摘要

现在认为细胞的氧化还原环境对于控制许多蛋白质的活性极为重要。在细胞凋亡过程中,细胞内氧化还原电位(E(h))变得更正,这可能对细胞凋亡机制产生影响。谷胱甘肽和细胞色素c可能既影响细胞氧化还原环境,又受其影响,因此在细胞凋亡进程中很重要。

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