Oran Betul, Celik Ismail, Erman Mustafa, Baltali Esmen, Zengin Nurullah, Demirkazik Figen, Tezcan Sabahat
Department of Medical Oncology, Hacettepe University Institute of Oncology, Ankara, Turkey.
Med Oncol. 2004;21(1):31-40. doi: 10.1385/MO:21:1:31.
The aim of this study was to investigate the association between menstrual, reproductive, and life-style factors and breast cancer in Turkish women. In a hospital-based case-control study in Ankara, 622 patients with histologically confirmed breast cancer were compared with 622 age-matched controls, admitted to the same hospital for acute and non-neoplastic diseases. Unconditional logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (CI) related to risk factors. Overall, menopausal status and age at menopause were found to be significantly associated with breast cancer. Having a full-term pregnancy and early age at first birth were associated with decreased breast cancer risk (OR = 0.45, 95% CI = 0.30-0.66; OR = 0.34, 95% CI = 0.22-0.53, respectively). Postmenopausal women with lactation longer than 48 mo had reduced risk of breast cancer (OR = 0.36, 95% CI = 0.14-0.93). In conclusion, decreased parity, late age at first birth, early menopause, and shorter duration of lactation were the most important determinants of breast cancer risk in Turkish women.
本研究旨在调查土耳其女性月经、生殖及生活方式因素与乳腺癌之间的关联。在安卡拉一项基于医院的病例对照研究中，将622例经组织学确诊的乳腺癌患者与622例年龄匹配的对照进行比较，这些对照因急性和非肿瘤性疾病入住同一家医院。采用无条件逻辑回归来估计与危险因素相关的比值比（OR）和95%置信区间（CI）。总体而言，绝经状态和绝经年龄被发现与乳腺癌显著相关。足月妊娠和早育与降低乳腺癌风险相关（OR分别为0.45，95%CI为0.30 - 0.66；OR为0.34，95%CI为0.22 - 0.53）。绝经后哺乳超过48个月的女性患乳腺癌风险降低（OR = 0.36，95%CI = 0.14 - 0.93）。总之，生育次数减少、初产年龄晚、绝经早以及哺乳时间短是土耳其女性乳腺癌风险的最重要决定因素。
