Madhavan Raghavan, Peng H Benjamin
Department of Biology, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, P.R. China.
J Neurocytol. 2003 Jun-Sep;32(5-8):685-96. doi: 10.1023/B:NEUR.0000020617.05656.68.
The clustering of acetylcholine receptors (AChRs) in muscle is a hallmark step in the development of vertebrate neuromuscular junctions (NMJs). It involves localized signaling, which is initiated by the activation of MuSK (muscle-specific kinase) and leads to the concentration and cytoskeletal anchoring of AChRs at the synapse, and global signaling, which traverses the muscle to disperse extra-synaptic AChR clusters. Here we review some of the recent findings that indicate important roles for the actin cytoskeleton and tyrosine phosphatases in mediating these processes.
肌肉中乙酰胆碱受体（AChRs）的聚集是脊椎动物神经肌肉接头（NMJs）发育的标志性步骤。它涉及局部信号传导，该过程由MuSK（肌肉特异性激酶）的激活引发，并导致AChRs在突触处的浓缩和细胞骨架锚定，以及全局信号传导，该信号穿过肌肉以分散突触外AChR簇。在这里，我们回顾一些最近的发现，这些发现表明肌动蛋白细胞骨架和酪氨酸磷酸酶在介导这些过程中发挥重要作用。
