对因情绪水平不同而培育的大鼠品系大脑中相关mRNA水平和蛋白质模式的分析。
Analysis of relative mRNA levels and protein patterns in brains of rat strains bred for differing levels of emotionality.
作者信息
Whatley S A, Perrett C W, Zamani R, Gray J A
机构信息
Department of Neuroscience, Institute of Psychiatry, Denmark Hill, London, UK.
出版信息
Behav Genet. 1992 Jul;22(4):403-13. doi: 10.1007/BF01066612.
mRNA and protein populations were studied in the brains of Maudsley reactive (MR) and Maudsley nonreactive (MNR) rat strains, which exhibit differing levels of emotionality. Translational analysis of forebrain mRNA indicated that the relative levels of two translation products (42 kDA, pI 5.0; 30 kDa, pI 5.8) were increased in the MR compared to the MNR strain. In addition, a charge-shift variant of a 36 kDa protein was present in the MR strain. Analysis of brain protein patterns indicated that a protein of 39 kDa, pI 5.0, was found to be more abundant in MR compared with MNR strains in both frontal cortex and hippocampus and the relative level of one protein (40 kDa, pI 5.8) was decreased in the frontal cortex.
在表现出不同情绪水平的莫兹利反应型（MR）和莫兹利非反应型（MNR）大鼠品系的大脑中研究了mRNA和蛋白质群体。前脑mRNA的翻译分析表明，与MNR品系相比，MR品系中两种翻译产物（42 kDa，pI 5.0；30 kDa，pI 5.8）的相对水平有所增加。此外，MR品系中存在一种36 kDa蛋白质的电荷转移变体。脑蛋白质模式分析表明，在额叶皮质和海马体中，与MNR品系相比，MR品系中一种39 kDa、pI 5.0的蛋白质含量更高，并且额叶皮质中一种蛋白质（40 kDa，pI 5.8）的相对水平降低。
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