Puzyrev V P, Lemza S V, Nazarenko L P, Panphilov V I
Population Genetics Laboratory, Tomsk Scientific Centre, Russian Academy of Medical Sciences.
Arctic Med Res. 1992 Jul;51(3):136-42.
The relationship between genetico-demographic parameters (endogamy, inbreeding, mating structure, gene diversity) and regularities of the prevalence of hereditary and common diseases (ischemic heart disease, arterial hypertension) and their risk factors in the North Khanty, a small, semi-isolated Siberian ethnic group of Finno-Ugric linguistic affinities, were studied. It has been shown that among hereditary diseases autosomal-dominant and polygenic ones are most frequent. Special features of the genetic liability to common diseases were described. The contributions of hereditary factors to the total variability of the 20 studied morphophysiological traits were shown to vary significantly.
对北汉特人（一个具有芬兰-乌戈尔语系亲缘关系的西伯利亚小半隔离族群）的遗传人口统计学参数（近亲通婚、近亲繁殖、交配结构、基因多样性）与遗传性和常见疾病（缺血性心脏病、动脉高血压）患病率规律及其风险因素之间的关系进行了研究。结果表明，在遗传性疾病中，常染色体显性和多基因疾病最为常见。描述了常见疾病遗传易感性的特点。研究表明，遗传因素对所研究的20种形态生理特征总变异性的贡献差异显著。
