新型1,2-苯并异噻唑基衍生物的合成、降血糖及毒理学评价
Synthesis, hypoglycemic and toxicological evaluation of new 1,2-benzisothiazolyl derivatives.
作者信息
Vicini P, Amoretti L, Caretta A
机构信息
Istituto di Chimica Farmaceutica e Tossicologica, Università di Parma.
出版信息
Farmaco. 1992 Mar;47(3):265-74.
PMID:1503591
Abstract
The synthesis of 1,2-benzisothiazol-3-ylguanidines, 1,2-benzisothiazol-3-ylbenzensulphonylureas and 1,2-benzisothiazol-3-ylbenzensulphonamides is described. Some of the new compounds showed moderate hypoglycemic activity but most of them caused serious acute toxic effects.
摘要
描述了1,2 - 苯并异噻唑 - 3 - 基胍、1,2 - 苯并异噻唑 - 3 - 基苯磺酰脲和1,2 - 苯并异噻唑 - 3 - 基苯磺酰胺的合成。一些新化合物表现出中度的降血糖活性，但大多数化合物会引起严重的急性毒性作用。
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