Wegrowski Yanusz, Maquart Francois-Xavier
Laboratory of Biochemistry, CNRS FRE 2534, Faculty of Medicine, IFR-53, 51095 Reims Cedex, France.
Crit Rev Oncol Hematol. 2004 Mar;49(3):259-68. doi: 10.1016/j.critrevonc.2003.10.005.
Glycosaminoglycans (GAGs) and proteoglycans (PGs) belong to a class of extracellular macromolecules necessary for the growth of any multicellular structures, including tumours. Transformed cells induce stromal reaction either per se or by activation of the mesenchymal cells. Tumour stroma contains several chondroitin sulphate and heparan sulphate proteoglycans. These proteoglycans and their glycosaminoglycan chains modify cell behaviour by interacting with different molecules such as growth factors, cytokines, chemokines, proteinases and their inhibitors. This review describes the main proteoglycans of tumour stoma and discusses their implication in the regulation of the activity of extracellular proteins and peptides.
糖胺聚糖（GAGs）和蛋白聚糖（PGs）属于一类细胞外大分子，是包括肿瘤在内的任何多细胞结构生长所必需的。转化细胞本身或通过激活间充质细胞诱导基质反应。肿瘤基质含有几种硫酸软骨素和硫酸乙酰肝素蛋白聚糖。这些蛋白聚糖及其糖胺聚糖链通过与生长因子、细胞因子、趋化因子、蛋白酶及其抑制剂等不同分子相互作用来改变细胞行为。本文综述了肿瘤基质的主要蛋白聚糖，并讨论了它们在调节细胞外蛋白质和肽活性中的作用。
