Kovalszky I, Jeney A, Lapis K
Semmelweis Orvostudományi Egyetem, Budapest, I. sz. Pathologiai és Kísérleti Rákkutató Intézet.
Orv Hetil. 1993 Sep 12;134(37):2019-26.
Proteoglycans are macromolecules containing a core protein to which glycosaminoglycan chains are covalently attached. The family contains several members with different structures and various functions. Some of them are elements of the extracellular matrix, while others are located to the cell surface playing important role in cell-cell and cell-extracellular matrix interactions. Present paper discusses the possible consequences of the alterations of proteoglycans observed in liver cirrhosis and liver tumors. It has to be emphasized however, that they are also involved in the pathomechanism of arteriosclerosis, Alzheimer-disease, immune diseases, arthritis, tumor progression and metastasis formation.
蛋白聚糖是一种大分子，其包含一个核心蛋白，糖胺聚糖链共价连接于该核心蛋白上。该家族包含几个具有不同结构和多种功能的成员。其中一些是细胞外基质的成分，而另一些则位于细胞表面，在细胞间和细胞与细胞外基质的相互作用中发挥重要作用。本文讨论了在肝硬化和肝肿瘤中观察到的蛋白聚糖改变可能产生的后果。然而，必须强调的是，它们也参与动脉粥样硬化、阿尔茨海默病、免疫疾病、关节炎、肿瘤进展和转移形成的发病机制。
