大型溞血红蛋白的分子适应性

Molecular adaptation of Daphnia magna hemoglobin.

作者信息

Zeis Bettina, Lamkemeyer Tobias, Paul Rüdiger J

机构信息

Institute of Zoophysiology, Westfälische Wilhelms-Universität, Hindenburgplatz 55, Münster 48143, Germany.

出版信息

Micron. 2004;35(1-2):47-9. doi: 10.1016/j.micron.2003.10.015.

DOI:10.1016/j.micron.2003.10.015

PMID:15036288

Abstract

Daphnia magna responds to changing environmental conditions impeding aerobic metabolism by synthesizing hemoglobin of adequate quantity and quality to maintain oxygen supply of the tissues. Hemoglobin subunit composition and its oxygen affinity were analyzed as a function of temperature as well as depending on the oxygen partial pressure of the medium. Additionally, the time course of acclimation to hypoxia was studied. Correlating structural and functional changes, the role of individual subunits for the increase in oxygen affinity is discussed.

摘要

大型溞通过合成数量和质量合适的血红蛋白来维持组织的氧气供应，从而应对阻碍有氧代谢的不断变化的环境条件。分析了血红蛋白亚基组成及其氧亲和力随温度以及培养基氧分压的变化情况。此外，还研究了适应低氧的时间进程。通过关联结构和功能变化，讨论了各个亚基对氧亲和力增加的作用。