Jaskiw George E, Simpson Catherine, Bongiovanni Rodolfo, Yamamoto Bryan K
Psychiatry Service 116A(B), Louis Stokes Cleveland Veterans Affairs Medical Center, 10000 Brecksville Road, Brecksville, OH 44141, USA.
Neurosci Lett. 2004 Feb 26;357(1):5-8. doi: 10.1016/j.neulet.2003.11.060.
It has been reported that tyrosine administration augments clozapine-induced dopamine (DA) release in the medial prefrontal cortex (MPFC). To characterize this effect and exclude possible confounds, we conducted a series of studies in which microdialysate collection started 24 h after probe implantation, a time at which most collected DA is thought to be impulse mediated. Tyrosine (25 or 50 mg/kg IP) administered 30 min after clozapine (10 mg/kg IP) augmented clozapine-induced MPFC but not striatal DA release. While tyrosine potentiation was also evident in both fasted animals and those with free access to food, the effective doses of tyrosine varied. We confirm that tyrosine administration can potentiate clozapine-induced MPFC DA release but note that the effect is not evident across all doses and conditions.
据报道，给予酪氨酸可增强氯氮平诱导的内侧前额叶皮质（MPFC）多巴胺（DA）释放。为了表征这种效应并排除可能的混杂因素，我们进行了一系列研究，其中在探针植入后24小时开始收集微透析液，此时大多数收集到的DA被认为是冲动介导的。在氯氮平（10mg/kg腹腔注射）后30分钟给予酪氨酸（25或50mg/kg腹腔注射）可增强氯氮平诱导的MPFC的DA释放，但不增强纹状体的DA释放。虽然酪氨酸增强作用在禁食动物和自由进食的动物中均很明显，但酪氨酸的有效剂量有所不同。我们证实给予酪氨酸可增强氯氮平诱导的MPFC的DA释放，但注意到这种效应在所有剂量和条件下并不明显。
