Matthews Elizabeth A, Dickenson Anthony H
Department of Pharmacology, University College London, Gower Street, London WC1E 6BT, UK.
Neurosci Lett. 2004 Feb 19;356(3):211-4. doi: 10.1016/j.neulet.2003.11.057.
A novel G-protein-coupled receptor with adenine identified as the endogenous ligand has recently been described. In vivo electrophysiological techniques in the rat were used to record the response of dorsal horn neurones in response to transcutaneous electrical stimulation to the hindpaw receptive field. Spinal adenine (1-1000 microg) exerted facilitatory effects on the electrically-evoked neuronal responses, in a mildly dose-related manner. After establishment of carrageenan-induced inflammation to the hindpaw this excitatory effect of adenine was still apparent, yet reduced. C-fibre-evoked responses and other nociceptive related measures were most susceptible to the effects of adenine, whereas non-nociceptive Abeta-fibre evoked activity remained unaffected. Thus, activation of the adenine receptor site, via spinally applied adenine, suggests a pronociceptive role in nociceptive sensory transmission.
最近描述了一种新型的G蛋白偶联受体，已确定腺嘌呤为其内源性配体。在大鼠中采用体内电生理技术记录背角神经元对后爪感受野经皮电刺激的反应。脊髓内注射腺嘌呤（1 - 1000微克）以轻度剂量相关的方式对电诱发的神经元反应产生促进作用。在角叉菜胶诱导后爪炎症形成后，腺嘌呤的这种兴奋作用仍然明显，但有所减弱。C纤维诱发反应和其他伤害性相关指标对腺嘌呤的作用最为敏感，而非伤害性Aβ纤维诱发的活动则不受影响。因此，通过脊髓内应用腺嘌呤激活腺嘌呤受体位点表明其在伤害性感觉传递中具有促伤害性作用。
