Niwa Yoshimitsu, Hamajima Nobuyuki, Atsuta Yoshiko, Yamamoto Kazuhito, Tamakoshi Akiko, Saito Toshiko, Hirose Kaoru, Nakanishi Toru, Nawa Akihiro, Kuzuya Kazuo, Tajima Kazuo
Department of Preventive Medicine/Biostatistics and Medical Decision Making, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan.
Cancer Lett. 2004 Mar 8;205(1):55-60. doi: 10.1016/j.canlet.2003.11.014.
To examine the possible association between cervical cancer and p73 G4C14-to-A4T14 in exon 2 and p53 Arg72Pro polymorphisms, an incident case-control study was conducted in Japanese. The cases were 112 cervical cancer patients. Controls were 320 healthy women and 122 non-cancer female outpatients. Risk estimation for each genotype by an unconditional logistic model demonstrated a possible association between the p73 A4T14 variant and the risk of cervical cancer in our Japanese population (OR = 1.57; 95%CI, 0.99-2.48, P = 0.053). There was no significant difference in the p53 Arg72Pro genotype frequency between the controls and cases.
为了研究宫颈癌与外显子2中p73基因的G4C14 - A4T14突变以及p53基因的Arg72Pro多态性之间的可能关联，在日本开展了一项病例对照研究。病例组为112例宫颈癌患者。对照组包括320名健康女性和122名非癌症女性门诊患者。通过无条件逻辑模型对每种基因型进行风险估计，结果表明在我们的日本人群中，p73基因的A4T14突变与宫颈癌风险之间可能存在关联（比值比=1.57；95%置信区间，0.99 - 2.48，P = 0.053）。对照组和病例组之间p53基因的Arg72Pro基因型频率无显著差异。
