Tranquilli Andrea L, Bezzeccheri Valeria, Giannubilo Stefano R, Scagnoli Caterina, Mazzanti Laura, Garzetti Giuseppe G
Department of Obstetrics and Gynecology, University of Ancona, Salesi Hospital, via Corridoni 11, 60123 Ancona, Italy.
Eur J Obstet Gynecol Reprod Biol. 2004 Mar 15;113(1):17-20. doi: 10.1016/S0301-2115(03)00369-5.
To assess whether amniotic fluid concentrations of nitric oxide (NO) and vascular endothelial growth factor (VEGF) in early pregnancy correlate to subsequent preeclampsia.
We performed a retrospective study to assess VEGF and NO on the second trimester amniotic fluid of 15 healthy women, and 15 women who subsequently developed preeclampsia.
In women with subsequent preeclampsia, both VEGF (213.19+/-78.42 pg/ml) and NO concentrations (4.31+/-1.02 micromol/mg creatinine) were significantly lower than healthy controls (VEGF 255.05+/-88.66 pg/ml; NO 5.02+/-1.57 microg/mg creatinine; P<0.05).
Our findings suggest that reduced VEGF may be responsible, at least in part, for the impaired vascular development which occurs in preeclampsia. Low concentrations of VEGF and NO in the second trimester may represent an impaired stimulus to vascular formation and endothelial regulation that induce placental disease and preeclampsia.
评估妊娠早期羊水中一氧化氮（NO）和血管内皮生长因子（VEGF）的浓度是否与随后发生的子痫前期相关。
我们进行了一项回顾性研究，以评估15名健康女性和15名随后发生子痫前期的女性妊娠中期羊水中的VEGF和NO。
在随后发生子痫前期的女性中，VEGF（213.19±78.42 pg/ml）和NO浓度（4.31±1.02 μmol/mg肌酐）均显著低于健康对照组（VEGF 255.05±88.66 pg/ml；NO 5.02±1.57 μg/mg肌酐；P<0.05）。
我们的研究结果表明，VEGF降低可能至少部分导致了子痫前期中出现的血管发育受损。妊娠中期VEGF和NO浓度低可能代表对血管形成和内皮调节的刺激受损，从而诱发胎盘疾病和子痫前期。
