Nap Annemiek W, Hamulyak Karly, van Oerle Rene, van Pampus Lizzy C M, Spaanderman Marc E, Damoiseaux Jan, Rosing Jan, Peeters Louis L
Department of Obstetrics and Gynecology, University Hospital Maastricht, P.O. Box 5800, Maastricht AZ 6202, The Netherlands.
Eur J Obstet Gynecol Reprod Biol. 2004 Mar 15;113(1):26-30. doi: 10.1016/S0301-2115(03)00329-4.
We determined the performance of a functional test for activated protein C (APC) resistance in formerly pre-eclamptic women and matched controls.
In our university medical center, we assessed the response to APC in plasma in 118 formerly pre-eclamptic women and in 57 healthy controls, we measured plasma levels of thrombophilic factors and we performed statistical analysis.
The incidence of APC resistance was significantly higher in formerly pre-eclamptics than in controls. Formerly APC resistant pre-eclamptics more often experienced intra-uterine growth restriction (IUGR) than their non-APC resistant counterparts.
APC resistance determined by this functional test is present in a large subgroup of formerly pre-eclamptics. A higher incidence of IUGR in this group suggests a more severe course of the experienced pregnancy complications. Additional study is needed to determine whether this test is sensitive in predicting recurrence of pre-eclampsia or IUGR.
我们测定了既往患有子痫前期的女性及匹配对照组中活化蛋白C（APC）抵抗功能试验的表现。
在我们的大学医学中心，我们评估了118例既往患有子痫前期的女性和57例健康对照者血浆对APC的反应，测量了血浆中血栓形成倾向因子水平，并进行了统计分析。
既往患有子痫前期的女性中APC抵抗的发生率显著高于对照组。既往对APC抵抗的子痫前期患者比非APC抵抗的患者更常出现宫内生长受限（IUGR）。
通过该功能试验确定的APC抵抗存在于很大一部分既往患有子痫前期的女性中。该组中IUGR的发生率较高表明所经历的妊娠并发症病程更严重。需要进一步研究以确定该试验在预测子痫前期或IUGR复发方面是否敏感。
