食欲行为的基因研究未来。

The future of genetic research on appetitive behavior.

作者信息

Kowalski Timothy J

机构信息

Department of CV/Endocrinology Biological Research, CNS/CV Pharmacology, Schering-Plough Research Institute, Kenilworth, NJ 07033, USA.

出版信息

Appetite. 2004 Feb;42(1):11-4. doi: 10.1016/j.appet.2002.12.001.

DOI:10.1016/j.appet.2002.12.001

PMID:15036778

Abstract

The risk for developing obesity has a significant genetic component. Several quantitative trait loci and candidate genes have been identified using current methodological approaches however the information gained thus far is insufficient to adequately explain the genetics underlying human obesity. The completion of a draft of the human genome sequence, the potential benefit of single nucleotide polymorphisms association studies for identifying risk conferring alleles, and developing functional genomics technologies promise to accelerate obesity gene discovery. These advances, used with current evaluative tools (murine molecular genetic techniques), may increase our understanding of human obesity, and ultimately provide better approaches to diagnosis and treatment.

摘要

肥胖发生风险具有显著的遗传成分。使用当前的方法已经鉴定出了几个数量性状基因座和候选基因，然而，迄今为止所获得的信息不足以充分解释人类肥胖背后的遗传学机制。人类基因组序列草图的完成、单核苷酸多态性关联研究在识别风险等位基因方面的潜在益处以及功能基因组学技术的发展，有望加速肥胖基因的发现。将这些进展与当前的评估工具（小鼠分子遗传学技术）相结合，可能会增进我们对人类肥胖的理解，并最终提供更好的诊断和治疗方法。